J&J Family of Companies Gene Editing Scientist in Beerse, Belgium
The candidate will join the Functional Genomics Group, within Translational Platform department of Discovery Science, to develop and implement cutting-edge approaches using gene editing tools to support the identification of small and large molecule therapeutics for disease indications, including Oncology, Immunology, Infectious Diseases, Neuroscience, and Cardiovascular and Metabolic Diseases. S/he will work in an exciting, interdisciplinary environment, overlapping the different stages of the discovery pipeline, by interacting with several internal and external groups. The candidate should be highly self-motivated and has experience managing a team of associate level staff. Responsibilities for the candidate include, design and execution of cellular experiments and screens using shRNA, CRISPR/Cas9, and other functional genomics tools for target identification, MOA characterization, and mechanisms of resistance and/or sensitivity to small and large molecules. The candidate is expected to be able to critically analyze their data and troubleshooting skills will be essential. S/he should demonstrate a sense of urgency, be organized and adhere to sensitive timelines.
Primary responsibilities (include, but are not limited to):
Supervise and guide junior research associates and work study students
Design and perform cellular and molecular experiments and assays.
Ability to perform proper tissue culture is a must. Cellular and molecular biology techniques include: transfections, transductions, RNAi and CRISPR/Cas9, microscopy, immunocytochemistry, flow cytometry, RTQ-PCR, western blotting, immunoprecipitation etc.
Experience with pooled genome scale functional genomics screens in vitro or in vivo and cell line engineering is strongly desired.
Interpret, troubleshoot and report on complex data. Basic statistical knowledge is mandatory.
Keep up-to-date on literature related to his/her field. Act as an expert resource in her/his scientific field and related disciplines. Propose novel and actionable assay ideas, aligned with internal and external scientific strategies and demands
Manage multiple experiments and projects simultaneously
Collaborate with stakeholders and business partners from all relevant functions and contribute to various projects within the organization
Communicate in a clear and professional manner, both in writing and orally
Present data in professional 'publication ready' format
Initiate and maintain external collaborations (e.g. with contract research organizations and academics)
Strong capabilities to collaborate with scientists in multiple disciplines.
Ph.D. degree or equivalent, with several years of productive post-doctoral experience in a high-quality academic, biotech or pharmaceutical environment.
Drug discovery experience in a biotech or pharmaceutical environment is a plus.
Personal skills and Competencies:
Strong management skills and ability to interact with junior team members in constructive and productive ways
Excellent interpersonal skills with the ability to interact effectively with people, internally and externally
Demonstrates creativity and novel approaches to solving scientific problems
Intellectually curious and well-informed on the latest scientific advances in the field
Strong record of publications
Detail-oriented, with excellent record-keeping skills
Excellent oral and written communication skills. Able to effectively present scientific data and concepts to international standards.
Janssen Pharmaceutica N.V. (7555)
Janssen Pharmaceutica N.V. (7555)